Email: nancy.karuri@dkut.ac.ke

Research Interests

  1. Engineering extracellular matrix mimics.
  2. Characterizing kinetics of assembly and degradation of extracellular matrices and their components.
  3. Creation and characterization of polymer-protein conjugates for protein stability.
  4. Modeling heat and mass transfer

Academic Qualifications

Qualification Institution Year
Ph.D. Chemical Engineering University of Wisconsin-Madison, Madison, WI USA May 2005
Bachelor of Engineering (Chemical)-1st Class Honors University of New South Wales, Sydney, Australia. April 1999

Professional History

Associate Professor, Mechanical Engineering, Dedan Kimathi University of Technology (DeKUT), Nyeri, Kenya – October 2016-Present

Senior Lecturer, Mechanical Engineering, Dedan Kimathi University of Technology (DeKUT), Nyeri, Kenya – August 2016-October 2016

Assistant Professor, Chemical and Biological Engineering, IIT, Chicago, IL, USA – August 2009-August 2016

Visiting Lecturer, Mechanical Engineering, DeKUT, Nyeri, Kenya  – May-August 2014, May-August 2015      

Visiting Professor, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA  – May-July 2013

Research Associate, Molecular Biology, Princeton University, Princeton, NJ, USA – February 2005-August 2009

Publications

  1. Ramanathan A, Karuri N, Proteolysis of decellularized extracellular matrices results in loss of fibronectin and cell binding activity, 2015, Biochemical Biophysical Research Communication, 459(2):246-251.
  2. Zhang, C, Ramanathan, A, Karuri, NW, Proteolytically stabilizing fibronectin without compromising cell and gelatin binding activity, 2014, Biotechnology Progress, 31(1):277-288.
  3. Zhang, C, Desai*, R, Perez-Luna, V, Karuri, NW, PEGylation of lysine residues improves the proteolytic stability of fibronectin while retaining biological activity, Biotechnology Journal, 2014, 9(8):1033-1043.
  4. Ramanathan, A, Karuri, NW, Fibronectin increases the rate of fibrin clot polymerization and alters matrix morphology, Biochemical and Biophysical Research Communications, 2014, 443(2):395-399.
  5. Zhang, C, Hekmatfer, S, Karuri, NW, A comparative study of polyethylene glycol hydrogels derivatized with the RGD peptide and the cell-binding domain of fibronectin, Journal of Biomedical Materials Research Part A, 2014, 102:170-179.
  6. Zhang, C, Hekmatfer, S, Ramanathan, A, Karuri, NW, PEGylated human plasma fibronectin is proteolytically stable, supports cell adhesion, cell migration, focal adhesion formation and fibronectin fibrillogenesis, Biotechnology Progress, 2013, 29:493-504.
  7. Kshatriya, PP, Karuri, SW, Chiang, C, Karuri, NW, A combinatorial approach for directing the amount of fibronectin fibrils assembled by cells that uses surfaces derivatized with mixtures of fibronectin and cell binding domains, Biotechnology Progress, 2012, 28:862-871.
  8. Chiang, C, Karuri, SW, Kshatriya, PP, Schwartz, J, Schwarzbauer, JE, Karuri, NW, A new surface derivatization strategy for combinatorial analysis of cell response to mixtures of protein domains, Langmuir, 2012, 28:548-556.
  9. Karuri, NW, Lin, Z, Rye, H, Schwarzbauer, JE, Probing the conformation of the fibronectin III1-2 domain by fluorescence resonance energy transfer, Journal of Biological Chemistry, 2009, 284:3445-3452.
  10. Karuri, NW, Porri, TJ, Albrecht, R, Murphy, CJ, Nealey, PF, Structural organization of the cytoskeleton in SV40 human corneal epithelial cells cultured on nano- and microscale grooves, Scanning, 2008, 30:1-9.
  11. Karuri, NW, Albrecht, R, Murphy, CJ, Nealey, PF, Nano- and microscale holes modulate cell-substrate adhesion, cytoskeletal organization and –β1 integrin localization in SV-40 Human Corneal Epithelial Cells, IEEE Transactions on Nanobioscience, 2006, 5:273-280.
  12. Karuri, NW, Nealey, PF, Murphy, CJ, Albrecht, RM, Structural organization of the cytoskeleton in SV40 human corneal epithelial cells cultured on nano- and microscale topography, Microscopy and Microanalysis, 2005, 11:182-183.
  13. Karuri, NW, Liliensiek, S, Teixeira, AI, Abrams, G, Campbell, S, Nealey, PF, Murphy, CJ, Biological length scale topography enhances cell substrate adhesion of human corneal epithelial cells, Journal of Cell Science, 2004, 117:3153-3164.